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17. SOLVENT-FREE
SYNTHESIS OF 3-ARYL-1-(2-ARYL-1H-INDOL-3-YL)PROP-2-EN-1-ONE AND
INVESTIGATION OF THEIR ANTIMICROBIAL ACTIVITI ES
Vijai
N. Pathak1,*, Ragini Gupta2, Neetu Gupta1
and V. M. Rao3
1Department
of Chemistry, University of Rajasthan, Jaipur- 302 004, INDIA
e-mail:
pathakvijain@yahoo.com
2Department
of Chemistry, Malaviya National Institute of Technology, Jaipur – 302
017, INDIA
email:
guptaragini@yahoo.com
3
Department of Botany, University of Rajasthan, Jaipur – 302 004, INDIA
Abstract:
Solvent-free synthesis of 3-aryl-1-(2-aryl-1H-indol-3-yl)prop-2-en-1-one
(3a-j) has been successfully accomplished in high yields and
lesser time by using Green Chemistry Techniques (Grindstone Chemistry
and Microwave irradiation). 3-Acetyl-2-phenylindoles (2a-j) on
treatment with either acidic or basic catalyst generates the
corresponding enolate which reacts with arylaldehydes affording the
desired title products. All the synthesized compounds have been
characterized by elemental analyses and spectral data (IR, PMR, and
FAB Mass). They have also been evaluated for their antibacterial and
antifungal activities and some of them have shown promising results
against S. cocci, P. floruscence, A. fumigatus and P.
chrysogenum.
Keywords:
Claisen-Schmidt reaction, 2-Phenylindole, 3-Acetyl-2-phenyl-indole,
Indolylchalcone, Grindstone Chemistry, Microwave irradiation.
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