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10.
Quantitative Determination of
Forskolin in Coleus forskohlii roots, extracts and dosage formsϯ
Katta Vijaykumar1, Papolu B. Murthy1, Sukala
Kannababu1, B. Syamasundar2 And Gottumukkala V.
Subbaraju*1
1
Laila Research Centre, Unit I, Phase III, Jawahar Autonagar,
Vijayawada – 520 007, India
2
Department of
Chemistry,
Acharya
Nagarjuna
University, Nagarjuna
Nagar–522 510,India
E-mail:
subbarajugottumukkala@hotmail.com
Abstract :
Forskolin, a labdane diterpenoid is a
novel anti-hypertensive, positive inotropic, platelet aggregation
inhibitory and adenylate cyclase stimulating agent. High performance
liquid chromatographic (HPLC) and high performance thin layer
chromatographic (HPTLC) methods for quantitative determination of
forskolin were developed and validated. The methods showed
satisfactory linearity, precision, good recovery and appropriate
limits of detection (LOD) and quantification (LOQ). The content of
forskolin was determined and the results obtained by HPLC and HPTLC
methods were in good agreement. The developed
methods are suitable for the quality control applications in
Coleus forskohlii roots, extracts and dosage forms.
Key Words:
Forskolin, Coleus forskohlii, dosage forms, HPLC, HPTLC
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