16- Synthesis and Antimicrobial Activity of 3,5-Disubstituted-1,3,4-thiadiazol-2-yliden by the Intramolecular Ring Transformation of 1,3,4-Oxadiazole

Magda A. Abdallah, Sayed M. Riyadh*, Ikhlas M. Abbas and Sobhy M. Gomha

Department of Chemistry, Faculty of Science, University of Cairo, Giza, Egypt:

*riyadh1993@hotmail.com

(Received 15 February 2006; accepted 01 March 2006)

 Abstract: The reaction of 5-(2-methyl-1H-indol-3-yl)-1,3,4-oxadiazole-2(3H)-thione 3 with hydrazonoyl halides 4 in ethanol in the presence of triethylamine under reflux provided the corresponding 3,5-disubstituted-1,3,4-thiadiazol-2-yliden 7. The structures of the products 7 were characterized based on spectral data and by chemical transformation. The biological activity of newly synthesized products 7 was also evaluated.

Key Words: 3,5-disubstituted-1,3,4-thiadiazol-2-yliden; antimicrobial activity; intramolecular ring transformation of 1,3,4-oxadiazole.

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