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Post-Harvest Stability Of 5-Hydroxytryptophan In Griffonia
Simplicifolia Seeds
Asiamah, I1*,
Adosraku, R.K2 and Owusu-Ansah, E1
1University
of
Cape
Coast, Department of Chemistry, Cape Coast,
e-mail:
ikasiamah@yahoo.com , Ghana
2Kwame
Nkrumah University of Science and Technology Department of
Pharmaceutical Chemistry, Kumasi, Ghana
Abstract:
This
study examines the stability of 5-Hydroxytryptophan (5-HTP) in
harvested Griffonia simplicifolia seeds and attempts to establish the
best temperature regime for storing harvested seeds. High Performance
Liquid Chromatography (HPLC) was used to determine 5-HTP levels of
seeds kept under different storage condition. The study revealed that
5-HTP is not stable in harvested seeds. The content fell at a rate of
4.62% w/w per month of storage under tropical atmospheric conditions.
Further studies conducted showed that refrigeration could not preserve
5-HTP in harvested seeds. The rate of decomposition was found to be
6.77% w/w per month. However, the rate of decomposition was
drastically reduced in seeds heated at 60oC for 30 min.
The average rate of fall in 5-HTP content was 1.79% w/w per month.
Key words:
Griffonia
simplicifolia, 5-Hydroxytryptophan, Antidepressant, Serotonin, High
Performance Liquid Chromatography
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