Abstract: A series of novel 4-phenyl-5-hepta-O-benzoyl-β-D-maltosylimino-3-arylimino-1,2,4-dithiazolidines (hydrochloride) were prepared by the interaction of N-hepta-O-benzoyl-β-D-maltosyl-S-chloro isothiocarbamoyl chloride with various 1-aryl-3-phenyl thiocarbamides. Elemental analysis, IR, ¹H NMR and mass spectral studies evidenced the structure of the newly synthesized compounds. Synthesized 1,2,4-dithiazolidines investigated for their antimicrobial activities against Proteus vulgaries, Escherichia coli, Salmonella typhimurium,  Staphylococcus aureus, Pseudomonas aeruginosa and Aspergilus niger.


Keywords: Isothiocarbamoyl chloride, 1-aryl-3-phenyl thiocarbamides, 1,2,4- dithiazolidines (hydrochloride), antimicrobial activity.