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11.
Synthesis and Pharmacological Evaluation of Some Novel
4-Methylphenylsemicarbazone Derivatives
aManmohan Singhal* & bArindam Paul
a
Department of Pharmacology, Jaipur National University, Jaipur,
Rajasthan, India
b Department of Pharmacy ,GD Memorial College of
Pharmacy, Jodhpur, Rajasthan, India
*Corresponding author: Tel.: +91-9829153193; fax: +91-1412753377;
E-mail
manu.research2@gmail.com
Abstract:
In the present study a series of 4-methylphenylsemicarbazone was
synthesized and evaluated for their antipyretic activity using
boiled cow milk induced pyrexia in rabbits. Based on the results
of an antipyretic study, compound 21 was the most active
compound. When the phenyl group of aldehydic and acetophenic
moiety of chalcone is substituted with hydroxy group the
compounds exhibited better activity in comparison to
substitution with the other groups like p-dimethyl amino groups.
The unsubstituted compounds showed very less protection against
pyrexia in comparison to the substituted compounds.
Key Words: Pyrexia,
Chalcone, Hyperthermia, Cow milk, Ligandscout.
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