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7. A
QSAR Study of Acetazolamide/Sulfanilamide Derivatives with Carbonic
Anhydrase (CA-II) Isozyme Inhibitory Activity
Rajneesh Kumara, Bhawnaa, Renu kumaria,
Madhu Guptaa* Venkateshwara*
a M.M.H. PG College,
Ghaziabad, India, email:
rajnishmmh@gmail.com
a* M.M.H. PG College, Ghaziabad, India, email:
madhuexe@gmail.com
a* Ideal Institute Of Technology, Ghaziabad, India, Venkateshwar,
v.vkt3@rediffmail.com
Abstract:
Quantitative Structure Activity Relationships (QSAR)
study on a pool of 18 bio-active sulfonamide compounds which
includes five acetazolamide derivatives, eight sulfanilamide
derivatives and five clinically used sulfonamides molecules as
drugs namely acetazolamide, methazolamide, dichlorophenamide,
ethoxolamide and dorzolamide. The tri-parametric model using MV,
PC and W comes out to be the best for modeling Log KI
activity.
Keywords: QSAR, topological indices, MLR, cross validation,
outliers.
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