Abstract: An accurate, specific and precise UV spectrophotometric method was developed for the simultaneous determination of naproxen (NP) and esomeprazole (EOZ) in a laboratory mixture of these two components. The method involves area under curve (AUC) method in the range 227-237nm and 296.5-306.5nm respectively, formation of simultaneous equation at 232nm and 301.5nm respectively, absorption correction method at 232nm λmax of naproxen, 239.2nm isoabsorptive point of NP & EOZ & 301.5nm for absorption ratio method by using methanol as a solvent. The linearity for both naproxen and esomeprazole was in the range of 1-5 µg/ml and 4-12µg/ml respectively. The % recovery was found to be 98.23% and 98.87% for naproxen and esomeprazole respectively indicating proposed method is accurate and precise for simultaneous estimation of naproxen and esomeprazole in bulk formulations.


Keywords: Naproxen, Esomeprazole, UV spectrophotometry, Simultaneous equation method, Absorption ratio, absorption correction method and Area under curve.