Abstract: The kinetics of oxidation of phenylpropanolamine hydrochloride (PPA) with sodium N-chlorobenzenesulfonamide or chloramine-B (CAB) catalyzed by Pd (II) chloride in perchloric acid médium has been studied at 308 K. Addition of chloride ions, mercuric acetate ions and the reduction product of CAB, benzenesulfonamide (BSA), have no significant effect on the rate of reaction. Reaction follows first order kinetics in case of chloramine –B and Pd(II)chloride.Increase in [H⁺] showed positive effect. The reaction was studied at different temperatures and the activation parameters have been computed from the Arrhenius plot. The stoichiometery of the reaction was found to be 1:1 and the main oxidation producís of PPA were found to be benzaldehyde and acetaldehyde.Formation and decomposition constant of CAB-PPA complexes in the reaction scheme have been evaluated. The conjúgate acid C₆H₅S0₂NHCl has been assumed to be the reactive species of chloramine-B.The observed results have been explained by plausible mechanisms and relative rate law has been deduced.
 

KEYWORDS: Phenylpropanolamine hydrochloride, chloramine-B, oxidation Kinetics, Pd(II)-catalysis, perchloric acid medium.