Abstract. QSAR studies have been performed on a series of N3-Subsituted Coformycin Aglycon Analogues, using physio-chemical parameters of substituent R, such as substituent hydrophobicity constant (π_R), molar refractivity (MR_R), field effect (F_R), resonance effect (R_R) and Hammett substituent constant (σ) as a measure of electronic properties. Adenosine 5’- monophasphate deaminase (AMPDA) inhibitor activity of   N3-Subsituted Coformycin Aglycon Analogues was found to have strong correlation with hydrophobicity constant (π_R) and presence of electron withdrawing group at ortho or para position of aromatic portion of substituent R. The present paper deals with the kinetics and mechanism of Ru(III) catalyzed oxidation of Ethylene glycol  in an alkaline solution of KBrO₃ carried out in the temperature range 30-45⁰C. Mercuric acetate has been used as a scavenger for Br- ion formed in the reaction mixture to prevent parallel oxidation by bromine. First order kinetics with respect to each [KBrO₃] and [Ru(III) chloride] was observed in the oxidation of Ethylene glycol. The reaction shows zeroth order with respect to Ethylene glycol and [OH^-], whereas a negative effect is observed for [Cl^-].
 

KEYWORDS: QSAR, Aglycon Analogues, Ru(III).