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7. Novel
complexes of Schiff base of cefadroxil: synthesis, spectral
characterization and biological evaluation
Thirumagal.B*1, Suman Malik1, Bharati Jain2
1Department of
Chemistry, Sadhuvasvani College, Bairagarh, Bhopal - 462 030, India.
2Department of Chemistry, SNGG PG College, Shivaji Nagar,
Bhopal - 462 016, India.
E-mail
address:
thirumagalbl@gmail.com
Abstract.
Metal complexes of β –lactum antibiotic Cefadroxil, having the
general composition ML2, (where M= Ca(II)/ Co(II)/ Cu (II) and
L=Deprotonated Schiff base of Cefadroxil) have been prepared.
The ratio of metals to Schiff base ligand was 1:2, as confirmed
through Job’s method of continuous variation. Further the
complexes were characterized by elemental and chemical analysis,
molar conductance, thermal and spectral (UV, IR, and mass)
studies. The IR spectral data suggests the involvement of
phenolic oxygen and azomethine nitrogen in coordination to the
central metal ion. On the basis of spectral studies, octahedral
geometry has been assigned for the complexes. The free ligand
and its metal complexes have been tested in vitro against a
number of microorganisms in order to assess their antimicrobial
properties.
KEYWORDS:
Complexes, Schiff base, spectral analysis, thermal analysis, and
antibacterial activity.
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