20.
QSAR studies on (biphenyl-4-sulfonyl) acetic acid Derivative against
Human Papilloma Virus (HPV)
SALONI MISHRA and J.P.MISHRA
Department of Chemistry, Feroze Gandhi College, Raebareli-229001,
U.P., India,
Email:
salonimishr@gmail.com
Abstract:
Biphenyl-4-sulfonyl acetic acid derivative is most emerging
target against HPV (human papilloma virus).It inhibits the
ATPase activity of HPV type 6E1 helicase. Quantitative Structure
Activity Relationship (QSAR) has been carried out in this
series. The 2D QSAR studies activity is positively influenced by
the molar refractivity resonance at the R1 and R2 positions.
Activity is also influenced positively by resonance effect on R1
position. The best QSAR model with good correlation coefficient
(r2=0.871), of high statistical significance (>99.9%)
well explained the variance in activity.
KEYWORDS: - QSAR, (biphenyl-4-sulfonyl) acetic acid
Derivative, Multiparameter Regression, Descriptors
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