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3.
Synthesis, anticonvulsant and toxicity evaluation of
4-Amino-5-phenyl-4H[1,2,4]triazole-3-thiol derivatives
P. K. Sahoo*1 and P. Behera2
1Sri
Vasavi Institute of Pharmaceutical Sciences, Pedatadepalli,
Tadepalligudem, West Godavari-534101, Andhra Pradesh, India
2K. G. R. L. College of Pharmacy, Bhimabharam, West Godavari
District, A. P., India
*Address For Correspondence: (Dr.) Prasanta Kumar Sahoo, Sri
Vasavi Institute of Pharmaceutical Sciences, Pedatadepalli,
Tadepalligudem, District: West Godavari – 534101, State: Andhra
Pradesh, India. Email ID:
psahoo.phar@gmail.com
Abstract:
A series of new 1,2,4-triazole derivatives were prepared by
condensing the methyl benzoate and methyl salicylate with
suitable reagents. All the titled compound structures were
established on the basis of their elemental analysis, FTIR,
1H NMR and Mass Spectral data. All the titled
compounds were screened for their anticonvulsant activity in
the MES model and were compared with the standard drugs
phenytoin sodium and carbamazepine. Out of the total titled
compounds studied PS01, PS06, PS07, PS09 and PS10 showed
comparable MES activity to phenytoin and carbamazepine after
0.5h. Compound PS09 showed to be more potent than
carbamazepine after 4h. Compound PS01 and PS 08 showed lower
neurotoxicity than phenytoin.
KEY
WORDS: Triazole, anticonvulsant and neurotoxicity.
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