|
3.
Phytochemical Screening and Biological Activity Studies on
Methanolic Extract of Psychotria Ankasensis.
*I. Asiamah1, G. Komlaga2,
F.S. Tayman1, R.K. Adosraku3, Y.
Opoku-Boahen1,
M. Fynn1, P. Brifo1 and N. Obeng1
1Department of Chemistry, School of Physical Sciences,
University of Cape Coast, Cape Coast, Ghana
2Department of Pharmacognosy, Faculty of Pharmacy, Kwame Nkrumah
University of Science and Technology, Kumasi, Ghana
3Deparment of Pharmaceutical Chemistry, Faculty of Pharmacy,
Kwame Nkrumah University of Science and Technology, Kumasi,
Ghana
Email:
ikasiamah@yahoo.com
Abstract:
The antimicrobial activity and Minimum
Inhibitory Concentration (MIC) of methanolic extract of
Psychotria ankasensis were evaluated against four bacteria:
Bacillus subtilis, Staphylococcus aureus, Pseudomonas
aeruginosa and Escherichia coli. The antimicrobial activity
was determined using the cup-plate technique. The same
technique was employed at four concentrations of the extract
to determine the MICs. Gentamycin was used as the positive
control. The methanolic extract showed reasonable activity
against all bacteria used. The average MIC ranged from 10.6
to 13.5 mg/ml. The test organisms used in this biological
screening have been implicated in a number of disease
conditions and reasonable activity, although in-vitro is an
indication that P. ankasensis could be potential source of
new antimicrobial agents. Preliminary phytochemical analyses
have revealed presence of alkaloids and saponins in the
methanolic extract.
KEY
WORDS: Psychotria ankasensis, antimicrobial, Minimum
Inhibitory Concentration (MIC), Gentamycin, gram-positive
and gram-negative bacteria.
<<< |
