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4. Cytotoxic coumarin from Calophyllum incrasaptum M.R Henderson & Wyatt-Smith (Guttiferae).
Jamilah Abbasa,c*, Muhammad Hanafia , L.B.S. Kardonoa*, Guo-Wei Qinb, Soleh Koselac
a Research Centre for Chemistry. Indonesian Institute of Sciences, PUSPIPTEK, Serpong,15314, Indonesia
bShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai,
555 Zu-Chong-Zhi Road , Shanghai 201203 . P.R. China
cDepartment of Chemistry, University of Indonesia, Depok 16424, Indonesia
*E-mail :
jamilahabbas@yahoo.com
Abstract: One new coumarin and one known calaustralin have been isolated from the stem bark of Calophyllum incrasaptum M.R Henderson & Wyatt-Smith (Guttiferae). The structures of these compounds were established by means of spectroscopic analysis, including extensive 2D NMR studies. Most of the isolated compounds were tested in vitro against P388, L1210, murine leukemia cell lines, Yashida Sarcoma and Hela human cancer cell lines. The new coumarin 1 (its trivial name azizcoumarin) was cytotoxic against Yashida sarcoma, L1210, and HeLa cell lines (IC50 = 4.12; 5.35 and 6.57 µg/mL) respectively, but was not cytotoxic against P388 ((IC50 > 100 µg/mL).
Key word index: Calophyllum incrasaptum M.R Henderson & Wyatt-Smith
Guttiferae, citotoxic. in vitro
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