8. Synthesis, Spectral Characterization and Biological Screening of Some 2-Amino Pyridines

Nitin Kumar, Sushma Drabu* 

Pharmaceutical Medicinal Chemistry Lab,  Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062, INDIA

e- Mail: sushma_drabu@yahoo.com

              nitinvermakr@yahoo.com

ABSTRACT

2-aminocyano pyridines were synthesized by reacting different chalcones with malonitrile and ammonium acetate in presence of ethanol. The initial materials, chalcones, were synthesized by mixing an aqueous solution of NaOH, acetophenone and aromatic aldehydes in ethanol. Purity of all the intermediate and titled compounds were checked by Thinlayer Chromatogfaphy (TLC) and the structure elucidation of each compound was characterized by 1H NMR, IR spectral data and elemental analysis results. All the synthesized compounds were also screened for their anti-inflammatory activity by carrageenan induced rat paw edema method. All synthesized compounds and the standard drug were taken in a dose of 20 mg/kg of body weight. Some of the synthesized compounds showed good anti-inflammatory activity when compared to standard drug indomethacin.

Keywords: Cyanopyridines, Chalcones,  Malonitrile, Anti-inflammatory activity.

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