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12- New Routes For The Synthesis of
5-NITRO-2-ARYL-1H-INDOLE-3-CARBOXALDEHYDE and evaluation of their
Antimicrobial Activities
Vijai N. Pathak1*, Meenakshi Jain1, Anjali
Tiwari1 and S.Rupadevi2
1Centre
of Advanced Studies,Department of Chemistry, University of Rajasthan,
Jaipur- 302 004, INDIA
2Department
of Biotechnology, Jaipur Engineering College and Research Centre,
Jaipur-303 905, INDIA
ABSTRACT:
Solvent free synthesis of 5-Nitro-2-aryl-1H-indole-3-carboxaldehyde (3a-i)
has been successfully accomplished in high yields and lesser time in
ecofriendly conditions by using Green Chemistry Techniques (Grindstone
chemistry, Microwave irradiation) and ultrasonication.
5-Nitro-2-arylindoles (2a-i)
on treatment with N,N-dimethylformamide (DMF) and phosphorus
oxychloride (POCl3) gave the desired title products. All
the synthesized compounds have been characterized by elemental
analyses and spectral data (IR, PMR and FAB Mass).They have also been
evaluated for their antibacterial and antifungal activities and some
of them have shown promising results against
S.aureus,
E.coli
and
A. niger,
R.bataticola.
Keywords:
5-Nitro-2- arylindoles, Grindstone chemistry, Microwave irradiation,
ulrasonication.
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